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JP Labs · Metabolic Research · Research Peptide

GLP3-R (Triple Agonist)

Triple-receptor GIP/GLP-1/glucagon agonist. The next generation of metabolic research compounds — available in 10mg, 20mg, 30mg, and 60mg.

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Metabolic Research · Research Compound

About GLP3-R

GLP3-R is the research designation for GLP3-R, a triple-receptor agonist that simultaneously targets GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors. This tripartite mechanism distinguishes it from earlier dual-receptor compounds and positions it as one of the most comprehensive metabolic research tools available.

The compound operates across three complementary pathways: GLP-1 receptor activation slows gastric emptying and reduces appetite signaling; GIP receptor activation enhances insulin secretion and may contribute to adipose tissue remodeling; glucagon receptor activation promotes hepatic glucose output and energy expenditure. Research into the combined effects of these three mechanisms is ongoing and represents a significant area of interest in metabolic science.

📚 Go Deeper
For a full breakdown of the triple GIP/GLP-1/glucagon receptor mechanism and research applications, see our What is GLP3-R? Research Guide. Not sure whether GLP3-R or GLP2-T fits your research design? See our side-by-side GLP3-R vs GLP2-T comparison guide. For more on how single, dual, and triple receptor agonists compare, read our GLP receptor agonist guide.
Purity
≥99%
HPLC-UV verified
Identity
LC-MS Confirmed
Mass spectrometry
Form
Lyophilized Powder
Requires reconstitution
Storage
Lyophilized: Room temp or 2–8°C
After reconstitution: 2–8°C
Available Sizes
10mg
Lyophilized powder · 99%+ purity
$75
20mg
Lyophilized powder · 99%+ purity
$120
30mg
Lyophilized powder · 99%+ purity
$175
60mg
Lyophilized powder · 99%+ purity
$280
🧪 Reconstitution
Reconstitute with Bacteriostatic Water. Standard protocol: 1 mL BAC Water per 10mg vial (10 mg/mL). For the 60mg vial, use 3 mL BAC Water (20 mg/mL) — a sterile transfer vial may be needed. Inject BAC Water slowly down the vial wall. Swirl gently. Do not shake. Refrigerate at 2–8°C after reconstitution. Visit our full Reconstitution Guide and Dosing Calculator for detailed instructions. For a complete reference on storage temperatures, light sensitivity, and shelf life across compound types, see our Peptide Storage 101 guide.
Research Context

Research Applications

GLP3-R is used in metabolic research investigating multi-receptor incretin pathway modulation. Research applications include studies of appetite regulation, energy homeostasis, insulin sensitivity, glucagon pathway interactions, and body composition under conditions of triple-receptor agonism. The compound is of particular interest in research comparing dual vs. triple receptor agonist mechanisms.

For research use only. All products sold by JP Labs are intended strictly for in vitro laboratory research. Not for human or veterinary use. Not FDA approved for any therapeutic purpose.
FAQ

Common Questions

What is GLP3-R?
GLP3-R is JP Labs's research name for a triple GIP/GLP-1/glucagon receptor agonist developed for metabolic research — the same receptor-target class studied under compounds like retatrutide. It is distinct from GLP-1 agonists (semaglutide) and dual GIP/GLP-1 agonists (GLP2-T) by virtue of its additional glucagon receptor activity.
What sizes is GLP3-R available in?
JP Labs carries GLP3-R in 10mg, 20mg, 30mg, and 60mg vials. The 20mg size is the most common starting point for research protocols.
How do I reconstitute GLP3-R?
Use Bacteriostatic Water. For 10mg: add 1 mL BAC Water (10 mg/mL). For 20mg: add 2 mL (10 mg/mL). For 30mg: add 3 mL (10 mg/mL). For 60mg: add 3 mL (20 mg/mL) — a sterile transfer vial is recommended. Refrigerate after reconstitution. Stable 28–42 days at 2–8°C.
Is GLP3-R the same as semaglutide or GLP2-T?
No. Semaglutide is a GLP-1 monoagonist. GLP2-T is a dual GIP/GLP-1 agonist. GLP3-R adds glucagon receptor agonism as a third mechanism, making it a triple agonist — a distinct compound with a different receptor profile.
Is GLP3-R the same as retatrutide?
GLP3-R is not sold or marketed as retatrutide. It is a research compound in the same mechanistic class — a GIP/GLP-1/glucagon triple receptor agonist — that researchers use to study the same three-receptor pathway retatrutide targets. Retatrutide itself is an investigational pharmaceutical still in clinical trials and is not available through JP Labs.
What is the difference between GLP3-R and GLP2-T?
GLP2-T targets GIP and GLP-1 receptors. GLP3-R targets GIP, GLP-1, and glucagon receptors. The additional glucagon component is believed to increase energy expenditure, which differentiates the two mechanistically.
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Regulatory Notice

None of the statements on this website have been reviewed or approved by the U.S. Food and Drug Administration. JP Labs products are not intended to diagnose, treat, cure, or prevent any disease or medical condition. All products are sold strictly for in vitro laboratory research purposes. They are not for human or animal use of any kind. DiPerna Services, LLC d/b/a JP Labs is not a compounding pharmacy or outsourcing facility as defined under Sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act.