About SS-31 (Elamipretide)
SS-31, also known as elamipretide, is a mitochondria-targeted tetrapeptide designed to selectively concentrate at the inner mitochondrial membrane through electrostatic interaction with cardiolipin — a phospholipid found almost exclusively in that membrane. By binding cardiolipin, SS-31 is studied for its ability to stabilize cristae membrane structure, support efficient electron transport chain function, and reduce excess reactive oxygen species production associated with mitochondrial dysfunction.
Because mitochondrial dysfunction is implicated in aging and in cardiac and skeletal muscle decline, SS-31 is frequently referenced in longevity and bioenergetics research models investigating mitochondrial membrane integrity and oxidative stress.
Research Applications
SS-31 is used in research investigating mitochondrial bioenergetics, cardiolipin-membrane interactions, and reactive oxygen species regulation. It is a common reference compound in cardiac and skeletal muscle aging research exploring mitochondrial membrane stability and oxidative stress pathways.