Melanocortin Receptor Research · Research Compound
About MT-2 (Melanotan 2)
Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide and analog of alpha-melanocyte-stimulating hormone (alpha-MSH), a naturally occurring hormone involved in pigmentation and a range of other physiological processes. MT-2 was originally developed in research exploring sunless tanning, and remains widely studied for its activity at the melanocortin receptor family.
MT-2 acts as a non-selective melanocortin receptor agonist. Activation of MC1R on melanocytes stimulates melanogenesis, shifting pigment production toward eumelanin (the darker pigment) and away from pheomelanin. Activation of MC3R and MC4R, expressed in the central nervous system, has been implicated in research on appetite regulation, libido, and body composition. This same melanocortin receptor research line is the precursor to PT-141 (bremelanotide), a more MC4R-selective compound studied specifically for sexual arousal research.
Research Context
Research Applications
MT-2 is used in research investigating melanocortin receptor pharmacology, melanogenesis and pigmentation pathways, appetite regulation, and body composition. It is also frequently referenced in research literature as a precursor to more receptor-selective melanocortin agonists, including MC4R-targeted compounds.
For research use only. All products sold by JP Labs are intended strictly for in vitro laboratory research. Not for human or veterinary use. Not FDA approved for any therapeutic purpose.
FAQ
Common Questions
What is Melanotan 2?
Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide and analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It was originally developed as part of research into sunless tanning agents and has since been studied for a broader range of melanocortin-receptor-related effects.
What is the mechanism of action?
MT-2 acts as a non-selective agonist at melanocortin receptors. Activation of MC1R on melanocytes stimulates melanogenesis — the production of eumelanin, the darker skin pigment. Activation of MC3R and MC4R, found in the central nervous system, has been implicated in research on appetite regulation, libido, and body composition. This receptor family is also the basis of the research line that led to PT-141 (bremelanotide).
Why is Melanotan 2 light-sensitive?
Like many peptides, MT-2 can degrade when exposed to prolonged light, particularly UV light. Protecting both the lyophilized powder and the solution from light helps preserve the peptide's structural integrity and stability over its storage life.