Mitochondrial & Redox Research · Research Compound
About 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is not a peptide — it is a quinolinium compound, and it is supplied as a lyophilised powder for laboratory use.
NNMT catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide and consuming both nicotinamide and SAM. Because nicotinamide is a precursor in the NAD+ salvage pathway, inhibiting NNMT is studied as a way to alter the balance between nicotinamide methylation and NAD+ regeneration, and to probe methyl-group availability in cell models.
Research Context
Research Applications
5-Amino-1MQ is used in research investigating NNMT enzyme kinetics and inhibitor selectivity, NAD+ salvage pathway flux, SAM/SAH methylation balance, 1-methylnicotinamide as a metabolic marker, and adipocyte metabolic signalling in the cell and rodent models reported in the literature.
For research use only. All products sold by JP Labs are intended strictly for in vitro laboratory research. Not for human or veterinary use. Not FDA approved for any therapeutic purpose.
FAQ
Common Questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is a quinolinium compound rather than a peptide, supplied as a lyophilised powder for laboratory research.
What is the mechanism behind NNMT inhibition?
NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide, consuming a NAD+ precursor in the process. Inhibiting the enzyme is studied for how it shifts NAD+ salvage pathway flux and methyl-group availability in cell models.
What research applications is 5-Amino-1MQ used for?
It is used in NNMT enzyme kinetics and inhibitor-selectivity work, NAD+ salvage pathway studies, SAM/SAH methylation balance assays, and adipocyte metabolic signalling research.
Is 5-Amino-1MQ available?
5-Amino-1MQ 50mg is available to preorder. Orders are accepted now and ship as soon as the batch arrives — we confirm the expected date when we confirm your order. Reach out anytime with research or batch questions.